:root {
    --kegg-red: rgb(255,110,120);
    --kegg-red-light: rgb(255,183,188);
    --kegg-main: #00bea5;
    --kegg-main-transparent: rgb(0,190,165,.25);
    --kegg-dark: #505050;

    --kegg-inactiveGreen: #b4e8e0;
    --kegg-activeGreen: #038473;
    --kegg-inactiveRed: #F26D6F;
    --kegg-activeRed: #B75454;
}

body {
    font-family: 'Roboto', sans-serif;
}
h1 {
    font-size: 2em;
    font-weight: 300;
    color: var(--kegg-dark);
    margin: 0;
    letter-spacing: -0.3px;
    line-height: 1.2em;
    font-kerning: normal;
}
h2 {
    font-size: 1.5em;
    font-weight: 300;
    margin: 0;
    letter-spacing: -0.3px;
    line-height: 1.2em;
    font-kerning: normal;
}
.p-25 {
    padding: 0.75rem!important;
}
/* Loader */
.loader-container {
	position: fixed;
	top: 50%;
	left: 50%;
	z-index: 2000;
    font-size: 25px;
}
.loader {
  width: 1em;
  height: 1em;
  border-radius: 80%;
  position: relative;
  text-indent: -9999em;
  -webkit-animation: load5 1.1s infinite ease;
  animation: load5 1.1s infinite ease;
  -webkit-transform: translateZ(0);
  -ms-transform: translateZ(0);
  transform: translateZ(0);
}
@-webkit-keyframes load5 {
  0%,
  100% {
    box-shadow: 0em -2.6em 0em 0em var(--kegg-red), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.5), -1.8em -1.8em 0 0em rgba(255,111,121, 0.7);
  }
  12.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.7), 1.8em -1.8em 0 0em var(--kegg-red), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.5);
  }
  25% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.5), 1.8em -1.8em 0 0em rgba(255,111,121, 0.7), 2.5em 0em 0 0em var(--kegg-red), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  37.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.5), 2.5em 0em 0 0em rgba(255,111,121, 0.7), 1.75em 1.75em 0 0em var(--kegg-red), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  50% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.5), 1.75em 1.75em 0 0em rgba(255,111,121, 0.7), 0em 2.5em 0 0em var(--kegg-red), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  62.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.5), 0em 2.5em 0 0em rgba(255,111,121, 0.7), -1.8em 1.8em 0 0em var(--kegg-red), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  75% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.5), -1.8em 1.8em 0 0em rgba(255,111,121, 0.7), -2.6em 0em 0 0em var(--kegg-red), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  87.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.5), -2.6em 0em 0 0em rgba(255,111,121, 0.7), -1.8em -1.8em 0 0em var(--kegg-red);
  }
}
@keyframes load5 {
  0%,
  100% {
    box-shadow: 0em -2.6em 0em 0em var(--kegg-red), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.5), -1.8em -1.8em 0 0em rgba(255,111,121, 0.7);
  }
  12.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.7), 1.8em -1.8em 0 0em var(--kegg-red), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.5);
  }
  25% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.5), 1.8em -1.8em 0 0em rgba(255,111,121, 0.7), 2.5em 0em 0 0em var(--kegg-red), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  37.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.5), 2.5em 0em 0 0em rgba(255,111,121, 0.7), 1.75em 1.75em 0 0em var(--kegg-red), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  50% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.5), 1.75em 1.75em 0 0em rgba(255,111,121, 0.7), 0em 2.5em 0 0em var(--kegg-red), -1.8em 1.8em 0 0em rgba(255,111,121, 0.2), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  62.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.5), 0em 2.5em 0 0em rgba(255,111,121, 0.7), -1.8em 1.8em 0 0em var(--kegg-red), -2.6em 0em 0 0em rgba(255,111,121, 0.2), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  75% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.5), -1.8em 1.8em 0 0em rgba(255,111,121, 0.7), -2.6em 0em 0 0em var(--kegg-red), -1.8em -1.8em 0 0em rgba(255,111,121, 0.2);
  }
  87.5% {
    box-shadow: 0em -2.6em 0em 0em rgba(255,111,121, 0.2), 1.8em -1.8em 0 0em rgba(255,111,121, 0.2), 2.5em 0em 0 0em rgba(255,111,121, 0.2), 1.75em 1.75em 0 0em rgba(255,111,121, 0.2), 0em 2.5em 0 0em rgba(255,111,121, 0.2), -1.8em 1.8em 0 0em rgba(255,111,121, 0.5), -2.6em 0em 0 0em rgba(255,111,121, 0.7), -1.8em -1.8em 0 0em var(--kegg-red);
  }
}

.loader-input {
    position: absolute;
    top: 0.3em;
    right: 1.3em;
    height: 1.7em;
    width: 1.7em;
}
.loader-input-sm {
    position: absolute;
    top: 0.8em;
    right: 0.8em;
    height: 1.4em;
    width: 1.4em;
}

/* Tables */
.table .thead-kegg-main th a {
    color: var(--white);
    display: flex;
}
.table .thead-kegg-main th a:hover {
    color: var(--kegg-red);
}
.table .thead-kegg-main th {
    color: var(--white);
    background-color: var(--kegg-main);
    border-color: var(--kegg-main);
}

.table .thead-kegg-red th {
    color: var(--white);
    background-color: var(--kegg-red);
    border-color: var(--kegg-red);
}

.clickable {
    cursor: pointer;
}
tr.active {
    background-color: var(--kegg-main-transparent);
}
tr td i {
    color: var(--kegg-main);
}

.table-hover tbody tr:hover {
    background-color: rgb(0,190,165,.075);
}




.sequence-container {
    padding: 0.3em;
}
.sequence-container table {
    display: flex;
    flex-flow: column;
    height: 100%;
    width: 100%;
}
.sequence-container table thead {
    /* head takes the height it requires,
    and it's not scaled when table is resized */
    flex: 0 0 auto;
}
.sequence-container table tbody {
    /* body takes all the remaining available space */
    flex: 1 1 auto;
    display: block;
    overflow-y: auto;
}
.sequence-container table tbody tr {
    width: 100%;
}
.sequence-container table thead,
.sequence-container table tbody tr {
    display: table;
    table-layout: fixed;
}
.sequence-container table td, table th {
    padding: 0.3em;
}

/* Navigation */
#logo {
    z-index: 22;
    float: left;
    opacity: 1;
    transition: opacity 0.1s;
}
#logo:hover {
    background: rgba(0, 190, 165, 0.05);
}
#logo img {
    height: 45px;
    margin: 0.5em;
}

a {
	text-decoration: none;
	color: var(--kegg-main);
	transition: color 0.2s;
	cursor: pointer;
}

a:hover {
    text-decoration: none;
	color: var(--kegg-red);
}

.environment {
    color: var(--kegg-red) !important;
}

/* Buttons */
button {
    border-width: 0;
}
.btn-kegg {
    height: 40px;
    letter-spacing: 0.5px;
    font-weight: 500 !important;
    color: white !important;
    background: var(--kegg-main);
    background-color: var(--kegg-main);
    border-color: transparent;
    padding: 10px 20px 10px !important;
    border-radius: 20px;
}
.btn-kegg:hover {
    background: var(--kegg-red) !important;
}

.btn-kegg-large {
    width: 11.5em;
}
.btn-kegg-medium {
    text-align: center;
    width: 7em;
}
.btn-kegg-small {
    height: calc(1.5em + .5rem + 2px);
    padding: .25rem .5rem !important;
    text-align: center;
    width: 7em;
}
.kegg-red {
    background: var(--kegg-red) !important;
}
.kegg-red-light {
    background: var(--kegg-red-light) !important;
}
.kegg-yellow {
    background: #F3B951 !important;
}
.btn-outline-kegg {
    color: var(--kegg-main);
    border-color: var(--kegg-main);
}
.btn-outline-kegg:hover {
    color: var(--white);
    background: var(--kegg-main);
}

/* Paging buttons */
.page-link.btn-kegg {
    letter-spacing: 0.5px;
    font-weight: 500;
    color: white;
    background-color: var(--kegg-main);
    padding: 10px 20px 10px;
    margin: 0;
    border: 0;
}
.page-link.btn-kegg:hover {
    z-index: 2;
    color: #0056b3;
    text-decoration: none;
    background-color: var(--kegg-red);
}

.page-item:first-child .page-link.btn-kegg {
    border-top-left-radius: 20px;
    border-bottom-left-radius: 20px;
    border-top-right-radius: 0;
    border-bottom-right-radius: 0;
    border-right: 1px solid white;
}

.page-item .page-link.btn-kegg {
    border-top-left-radius: 0;
    border-bottom-left-radius: 0;
    border-top-right-radius: 0;
    border-bottom-right-radius: 0;
    border-left: 1px solid white;
    border-right: 1px solid white;
}
.page-item .page-link.btn-kegg.disabled:hover {
    background-color: var(--kegg-main) !important;
}

.page-item:last-child .page-link.btn-kegg  {
    border-top-left-radius: 0;
    border-bottom-left-radius: 0;
    border-top-right-radius: 20px;
    border-bottom-right-radius: 20px;
    border-left: 1px solid white;
}

/* Chart */
.canvasGroup {
    position: -webkit-sticky;
    position: sticky;
    top: 0;
    background-color: var(--white);
    z-index: 1;
}

/* Checkbox tri-state */
[role="checkbox"] {
  display: inline-block;
  position: relative;
  padding-left: 1.4em;
  cursor: default;
}

[role="checkbox"]::before,
[role="checkbox"]::after {
  position: absolute;
  top: 50%;
  left: 7px;
  transform: translate(-50%, -50%);
  content: '';
}

[role="checkbox"]::before {
  width: 14px;
  height: 14px;
  border: 1px solid rgb(168, 168, 168);
  border-radius: 0.2em;
  background-image: linear-gradient(to bottom, rgb(238, 237, 238), #fff 30%);
}

[role="checkbox"]:active::before {
  background-image: linear-gradient(to bottom, rgb(188, 184, 188), rgb(238, 237, 238) 30%);
}

[role="checkbox"][aria-checked="false"]::before {
  border-color: var(--kegg-red);
  background: rgb(254,110,120);
  background-image: linear-gradient(to bottom, rgb(254,110,120), var(--kegg-red));
}

[role="checkbox"][aria-checked="true"]::before {
  border-color: rgb(1,190,165);
  background: rgb(0,190,165);
  background-image: linear-gradient(to bottom, rgb(1,190,165), rgb(0,190,165));
}

[role="checkbox"][aria-checked="false"]::after {
  display: block;
  width: 8px;
  border-bottom: 0.125em solid #fff;
  transform-origin: center center;
}

[role="checkbox"][aria-checked="false"]:active::after,
[role="checkbox"][aria-checked="true"]::after {
  display: block;
  width: 0.25em;
  height: 0.4em;
  border: solid #fff;
  border-width: 0 0.125em 0.125em 0;
  transform: translateY(-65%) translateX(-50%) rotate(45deg);
}

[role="checkbox"][aria-checked="false"]:active::before,
[role="checkbox"][aria-checked="true"]:active::before {
  background-image: linear-gradient(to bottom, rgb(1,190,165),rgb(0,190,165));
}

[role="checkbox"]:focus {
  outline: none;
}

[role="checkbox"]:focus::before {
  width: 16px;
  height: 16px;
  box-sizing: content-box;
  border-color: rgb(0,190,165);
  border-width: 2px;
  border-radius: calc(0.2em + 3px);
  box-shadow: inset 0 0 0 1px var(--kegg-main-transparent);
}

/* Custom checkbox */
/* The container */
.container {
  display: block;
  position: relative;
  padding-left: 35px;
  margin-bottom: 0 !important;
  cursor: pointer;
  font-size: 18px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}

/* Hide the browser's default checkbox */
.container input {
  position: absolute;
  opacity: 0;
  cursor: pointer;
  height: 0;
  width: 0;
}

/* Create a custom checkbox */
.checkmark {
  position: absolute;
  top: 0;
  left: 0;
  height: 25px;
  width: 25px;
  background-color: #eee;
}
.checkmark-sm {
  height: 22px;
  width: 22px;
}

/* On mouse-over, add a grey background color */
.container:hover input ~ .checkmark {
  background-color: #ccc;
}

/* When the checkbox is checked, add a blue background */
.container input:checked ~ .checkmark {
  background-color: var(--kegg-main);
}

/* Create the checkmark/indicator (hidden when not checked) */
.checkmark:after {
  content: "";
  position: absolute;
  display: none;
}

/* Show the checkmark when checked */
.container input:checked ~ .checkmark:after {
  display: block;
}

/* Style the checkmark/indicator */
.container .checkmark:after {
  left: 9px;
  top: 6px;
  width: 5px;
  height: 10px;
  border: solid white;
  border-width: 0 3px 3px 0;
  -webkit-transform: rotate(45deg);
  -ms-transform: rotate(45deg);
  transform: rotate(45deg);
}
.container .checkmark-sm:after {
  left: 8px;
  top: 5px;
}

/* Date Picker */
.daterangepicker td.in-range {
    background-color: var(--kegg-main-transparent);
}
.daterangepicker td.active, .daterangepicker td.active:hover {
    background-color: var(--kegg-main);
}
.daterangepicker td.available:hover, .daterangepicker th.available:hover {
    background-color: var(--kegg-red-light);
}

/* Calendar */
#calendar-container {
    position: fixed;
    top: 150px;
    left: 20px;
    right: 20px;
    bottom: 20px;
}
.fc .fc-button-primary {
    background-color: var(--kegg-main);
    border-color: var(--kegg-main);
}
.fc .fc-button-primary:not(:disabled).fc-button-active, .fc .fc-button-primary:not(:disabled):active,
.fc .fc-button-primary:hover, .fc .fc-button-primary:disabled {
    background-color: var(--kegg-red);
    border-color: var(--kegg-red);
}
.fc .note, .note {
    font-size: 15px;
    color: #000;
    padding: 5px;
}
.fc .icon, .icon {
    height: 17px;
    margin: 0 5px;
}
.note-label {
    height: 32px;
    width: 74px;
    font-size: 16px;
    text-align: center;
    margin: 0 5px;
    padding: 5px;
    color: #000;
    border-radius: 6px;
}
.fc .note-circle, .note-btn {
    color: var(--kegg-activeGreen);
    height: 32px;
    width: 32px;
    font-size: 20px;
    text-align: center;
    border-radius: 25px;
    border: 1px solid var(--kegg-inactiveGreen);
    display: inline-block;
    margin: 0 5px;
}
.fc .note-circle.active, .note-btn.active {
    background-color: var(--kegg-activeGreen);
    color: #fff;
}
.fc .note-circle.inactive, .note-btn.inactive {
    background-color: #fff;
}
.note-btn:hover {
    background-color: var(--kegg-inactiveRed);
    color: #fff;
}
.fc .fc-bg-event, .fc .fc-day-other .fc-daygrid-day-top {
    opacity: 1;
}
.fc .fc-daygrid-day-number, .fc .fc-daygrid-day-number:hover {
    color: #555;
}
.fc-icon-question-circle:before {
    font-family: "Font Awesome 5 Free";
    content: "\f059";
}

/* Forms */
.form-control, input.note-label {
    border: 1px solid var(--kegg-inactiveGreen);
}
.form-control:focus {
    box-shadow: 0 0 0 0.2rem var(--kegg-main-transparent);
}
/* Tippy.js */
.tippy-box[data-theme~='kegg'] {
  border: 1px solid var(--kegg-inactiveGreen);
}
.table tbody tr td span {
    cursor: default;
}